Abstract : This study analyzes the relationship among eHealth profiles across 27 European Union Member States. It builds on prior research that uses multivariate statistical methods to provide a cross-country analysis on two dimensions: ICT penetration and availability compared with eHealth access and usage among health professionals. Based on the quantitative indicators/metrics used in our study, our results reveal that four distinct country groupings emerge as frontrunners, followers, leapfroggers and laggards. Frontrunners combine a strong ICT infrastructure with relatively high adoption of eHealth technologies. Our study suggests that a one-size-fits-all approach to health IT is not recommended for EU Member States because policy-makers at the national level need to develop an eHealth roadmap that reflects national, regional and local conditions that go beyond technical imperatives.